Opsonization but not pretreatment of equine macrophages with hyperimmune plasma nonspecifically enhances phagocytosis and intracellular killing of Rhodococcus equi
نویسندگان
چکیده
منابع مشابه
Development of Hyperimmune Equine Plasma to Virulence Associated Protein A (VapA) of Rhodococcus equi
Procedure – A proprietary formulation of ATCC 33701 Rhodococcus equi known to contain the virulence plasmid was developed and tested on 72 horses. Antibody levels to Rhodococcus equi Virulence associated protein A (VapA) were determined relative to a Standard Plasma. A clinical trial was performed on 28 foals. Seven foals were administered hyperimmune plasma and seven foals were administered pu...
متن کاملSurvival of foals with experimentally induced Rhodococcus equi infection given either hyperimmune plasma containing R. equi antibody or normal equine plasma.
The purpose of this study was to determine if colostrum-deprived foals with experimentally induced Rhodococcus equi pneumonia have a decreased severity of the disease and decreased mortality rate when given hyperimmune (HI) R. equi antibody plasma (R. equi titer at least 100 % and virulence-associated protein A [VapA] at least 10000) prophylactically versus when given normal equine plasma (R. e...
متن کاملThe equine antimicrobial peptide eCATH1 is effective against the facultative intracellular pathogen Rhodococcus equi in mice.
Rhodococcus equi, the causal agent of rhodococcosis, is a major pathogen of foals and is also responsible for severe infections in immunocompromised humans. Of great concern, strains resistant to currently used antibiotics have emerged. As the number of drugs that are efficient in vivo is limited because of the intracellular localization of the bacterium inside macrophages, new active but cell-...
متن کاملPhagocytosis by macrophages of mycoplasma pneumoniae after opsonization by complement.
Mycoplasma pneumoniae cells are not phagocytized by peritoneal macrophages without opsonization. They are taken up after treatment with complement or antibody.
متن کاملEffect of hyperimmune plasma on the severity of pneumonia caused by Rhodococcus equi in experimentally infected foals.
This study evaluated the prophylactic effectiveness of hyperimmune plasma (HIP) as an aid in the prevention of pneumonia caused by experimental infection with Rhodococcus equi. Thirty neonatal foals were administered R. equi HIP or saline at 2 days of age and were infected with virulent R. equi at 7 days. All foals developed signs or symptoms of respiratory disease. Radiographic scores on day 2...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2020
ISSN: 0891-6640,1939-1676
DOI: 10.1111/jvim.16002